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The concomitant usage of DEMEROL Tablets or Oral Solution and CYP3A4 or CYP2B6 inducers can decrease the plasma focus of meperidine [see Medical Pharmacology (12.three)], causing decreased efficacy or onset of a withdrawal syndrome in clients who may have developed Bodily dependence to meperidine [see Warnings and Safeguards (5.Serotonin syndr

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